"Talking about her mental health, Katy Perry said "Well I haven't shaved my head yet" in a reference to Britney Spears".
In 2007 Britney Spears suffered from a very public meltdown during which she was recorded shaving her head and fighting with paparazzi.
Billboard proclaimed, "Katy Perry Embraces Her Wokeness - And It Works...one of music's biggest stars is once again dominating conversations". Not cute! Good luck with that new single, sis", one viewer wrote before another added, "Don't throw shade at Britney 2.
At the end of the song, Katy yelled "no hate", a phrase that has also been echoed in anti-Trump protests.
"How'd that go?" Seacrest asked.
Seacrest graciously didn't linger on her faux-pas instead commenting on the 32-year-old singer's new blonde hair and her new politically-charged single.
But social media took notice and slammed Perry hard for dragging up Britney's unfortunate past, especially in light of how far she has come in the decade since.
Singer Katy Perry speaks during a get out the early vote rally as she campaigns for Democratic presidential candidate Hillary Clinton at UNLV on October 22, 2016 in Las Vegas, Nevada. I think it's definitely a new era for me. "I'm nearly moments away from that, obviously".
During the performance, she circled a white house and picket fence onto which a number of scenes were projected, before being joined by Skip Marley, who contributes vocals to the song.
And that's not all - she made a political statement. She began to act erratically, shaved her head and attacked a paparazzo's vehicle with an umbrella. In 2011, "I Kissed a Girl" was nominated for best female pop vocal performance, as was "Hot n Cold" the following year. Last week, the Spears' family asked for thoughts and prayers as Britney's niece Maddie rebounded from a life-threatening ATV accident.