Scotland now sit in third place in the Six Nations table and while they are now outsiders for the trophy behind England and Ireland, an unexpected victory in what has been a much-improved campaign from Cotter and Scotland will see that all change going into the last weekend.
If Farrell, who sat out training yesterday with a knee injury, misses out, Ben Te'o will start instead and George Ford will take over the goalkicking.
Scotland: S Hogg (Glasgow); T Seymour (Glasgow), H Jones (Stormers), A Dunbar (Glasgow), T Visser (Harlequins); F Russell (Glasgow), A Price (Glasgow); G Reid (Glasgow), F Brown (Glasgow), Z Fagerson (Glasgow), R Gray (Toulouse), J Gray (Glasgow), J Barclay (Scarlets, capt), H Watson (Edinburgh), R Wilson (Glasgow).
The Triple Crown involves beating all the other British home nations - and Ireland (which, in rugby, includes Northern Ireland).
Replacements: Ford, Dell, Berghan, Swinson, Du Preez, Pyrgos, Weir, Bennett.
The Red Rose have won 17 successive matches - 16 under the guidance of head coach Eddie Jones - and will match New Zealand's unprecendented winning streak with a win in south west London.
Aussie Jones named an nearly identical team to face Scotland as his side push for an 18th straight win.
The England coach aimed a sly dig at Italy's tactics while suggesting that he thought Romain Poite had not understood the laws of the game correctly, rather than his players.
When is England vs Scotland? He will lead England out on Saturday.
But he could now be a doubt for the Six Nations game.
Victory for England over Scotland would give the defending RBS 6 Nations champions a record-equalling 18th consecutive win and put them one win away from a second straight Grand Slam. "He'll be alright. I think he'll be alright".
"We don't go into games being scared of the opposition", he said.
They shipped six penalties at scrum-time in defeat to France and will face an experienced England front row hoping to gain a similar advantage.
"We're focused on ourselves; we want to give our fans a really good performance". "Emotionally it always feels like we're there in the right place but maybe it just comes down to the individuals making sure they switch on and take the risks". Jonny's brother Richie has made more tackles (41) than anyone else without missing one so far.