Tottenham went six games without a win in all competitions earlier in the season when Kane suffered a similar injury.
The rumours are starting to circulate that Pochettino has not given up hope of attracting the South American to White Hart Lane, with potential scope for another attempt to sign him this summer. It is noticeable that the Saints have significantly improved over the last period, but we will see if it is going to be enough on Sunday afternoon.
"It's frustrating because we can do better, but we played a strong game against second in the table and played at a good level".
The Lilywhites head into the game fresh from having secured their spot in the FA Cup semi-finals against Chelsea next month. Their cup run this season has been very impressive and they really should've walked away with the trophy.
"We need to assess him day-by-day".
"I know Jansson very very well", said Vertonghen. "We trust completely our doctor and physios and that department who look after them in the best way". Kyle Walker, Victor Wanyama, Harry Kane, Denny Rose and Erik Lamela are all sidelined, but the good info is that Mousa Dembele is fit again and could see some minutes on the pitch.
Tottenham Hotspur manager Mauricio Pochettino has admitted that he held private talks with Vincent Janssen in order to give the striker a "wake up call". "Yes, you will always miss your main striker but what we can do if he is injured is to win the game and score goals". "We still played the same system, it was just a different player, Sonny, up top instead of Harry".
Pochettino, though, believes his squad has grown in strength as the season has progressed and placed his faith in Son Heung-Min to fill the gap left by Kane and provide the focal point to Tottenham's attack.
Mauricio Pochettino, the Tottenham manager, declined to disclose how Walker picked up the injury during his pre-match press conference today.
"They deserve it and we wish them well".
Alli stepped up to take it himself and confidently slotted the ball into the bottom corner of the net to put his side two goals in front.
Southampton striker Manolo Gabbiadini was inches away from an equaliser with a shot that shook the side-netting but the Italian limped off shortly afterwards with a groin injury.