Keylor Navas' poor form this season means a new keeper reportedly remains high on the agenda at the Santiago Bernabeu but Mourinho does not want De Gea to become side-tracked as his EFL Cup winners chase Europa League glory and a top-four spot in the Premier League.
"We want to fight in the Premier League until it's mathematically impossible but the Premier League, we cannot win it, and the Europa League we can", admitted Mourinho after the Sunderland match.
View the video above for the full thoughts of Jose Mourinho on his strongest Man Utd XI vs Anderlecht. I can forget about the transfer fee, it's in the past, I think about the pitch and doing good for the team - that's it.
"For me this coach is very important for us and every young player at Manchester United". We always want to do more. In the Europa League, we lose a match and we are in trouble.
Goalkeeper David De Gea also missed Sunday's 3-0 victory at the Stadium of Light due to a hip problem but thankfully Mourinho has confirmed the injury isn't anything serious. They might clinch another Europa League berth in the event the season ended today, however they understand they are able to reach a Champions League position when they win the EL this season.
"Every single game is massive now", Shaw told his pre-match press conference. We have to go back to the Champions League.
"We hope he can deliver again because it's the motivation of everybody in the club to go to the final and I believe maybe he has a little extra motivation because the final is in Sweden and because he's never played in a European cup final in such an awesome career he's had". Regardless of the fact both squads will be shorthanded, Anderlecht is going to have rough time trying to beat the likely lack of Teodorczyk upfront.
"We have the chance, we have everything to do it: we have the manager, the staff, the players". However, Romero has been United's preferred choice in European competition this season, having started seven of their 10 games in the Europa League this season. Celta Vigo take on Genk in Spain in the other quarter-final.
The Red Devils have been knocked out of two of their last three European quarter-final ties, losing out to Bayern Munich in the 2009/10 and 2013/14 Champions League, while beating Chelsea in 2010/11.