Former Chelsea coach Jose Mourinho host his old team the first time - after losing both games at Chelsea this season in defeats that have combined for a 5-0 score.
Mourinho's side have also been involved in an ongoing scrap for a Champions League place, and head into today's game with Chelsea six points adrift of fourth-place Liverpool with two games in hand.
Premier League leader Chelsea will be facing Manchester United in what will probably be one of the most watched football derbies this season.
Perhaps Jose is still a bit bitter over his exit from Chelsea.
The Red devils go into this match on the back of a 1-1 draw against Anderlecht in the Europa League.
That has put them in pole position to win a second title in three years and Conte concedes he is very pleased with his team so far.
Meanwhile, David de Gea is set to return as Manchester United's goalkeeper.
He had been taunted by Chelsea fans on his two trips to Stamford Bridge since being axed - a 4-0 league defeat in October followed by a 1-0 FA Cup quarter-final loss last month.
Who do you want to win, HollywoodLifers? They showed more desire, more ambition, more motivation to win. "So, let's be positive about it and hopefully go and win this game", MUTV quoted Pogba as saying.
So now that Kane is back and Tottenham is four points behind Chelsea with just six games left, the title race is automatically back on, right?
Whether this season gets marked as a success now essentially comes down to how they perform in the Europa League, which the Special One has himself admitted in recent weeks by prioritising a competition that he refused to give a second look to in the autumn.
His tactics were spot on, as they often are in big games. Manchester United teammates celebrate after scoring during the English Premier League soccer match between Manchester United and Chelsea at Old Trafford stadium in Manchester, Sunday, April 16, 2017. Over in the USA, you'll want NBCSN or Telemundo. However, the Nigerian returned from a toe injury against Bournemouth and Chelsea have no injuries and suspensions and Conte could name an unchanged side today.
"I like to think results are important, but they are not everything".
He said: "I think we have had very good performances - Arsenal here, Tottenham here, when we played really well".
"You need to be protected if you're finding form hard to find, so it's certainly not a strategy I would promote".
"The last time they played was last weekend".
Manchester United face Chelsea on Sunday with a burden of an eight match winless streak against the Blues.