"The Champions League would be the icing on the cake but that's it, not more".
A draw also would allow Liverpool to overtake and Arsenal to tie Manchester City on points, and a range of scenarios could enter Manchester City into a one-game Champions League playoff for third or fourth place.
The Reds welcome Boro to Anfield on Sunday afternoon, with a win securing a top-four finish for just the second time since 2008/09.
The Gunners are in desperate need of a favour from already relegated Boro as they travel to Liverpool.
Klopp is hopeful forward Roberto Firmino will be fit to return.
Steve Agnew will be without three important players through injury, with Victor Valdes, Gaston Ramirez and Daniel Ayala all sidelined.
Liverpool take on Middlesbrough on Sunday May 21.
Champions League qualification is in Liverpool's hands but this will still not stop the majority in attendance at Anfield from looking at their phones and checking the scores in the other matches.
"Losing our place in the Premier League is the biggest disappointment and something that has been hard to accept".
Boro will go into the match with absolutely nothing to lose and they'll want to give their fans the ideal sendoff before saying farewell to Premier League football.
The Europa League campaign last season brought some memorable nights at Anfield, in particular the comeback win over Borussia Dortmund in the quarter-finals, but that competition does not have the same allure.
Defoe has scored 15 of Sunderland's 28 Premier League goals this season.
Middlesbrough have attempted the fewest shots in total (342) and shots on target (97) this season in the Premier League.
Both he and Valdes have been busy this season and our goal difference is testament to their performances, considering we very rarely attack teams. Their form hasn't been great against the lesser teams, but they have to win.
He said: "What you want is that all teams have a go and they fight".
"Yes. I said before Champions League is a wonderful competition", he said this morning".
"There was the right balance in terms of being up for the game but not getting carried away and I've felt the same this week". The Reds captain has been sidelined since February with the problem and has not yet returned to training.
However, despite Liverpool's long-standing interest, it is believed that Spurs are winning the race for the teenager thanks to their location, with Sessegnon said to favour a transfer which would keep him in London. Enter your predictions for free here.