Arsene Wenger's Arsenal are at home again, and will face lower league opposition in Championship side Norwich City.
As for Chelsea, their lead-up to the Carabao Cup game involves a home game in the Champions League against Italian side AS Roma, then another home game against Watford before welcoming Everton, followed by a trip to AFC Bournemouth.
The Blues fielded plenty of youth with Ethan Ampadu becoming the first player born this millennium to make a senior Chelsea appearance. It was nothing more than a consolation goal for Lloyd Dyer, however it gave the Burton fans something to cheer about on a night United cruised through.
A brace from Dominic Calvert-Lewin and solitary strike from Oumar Niasse saw Everton claim a 3-0 win over Sunderland.
Wilshere was one of them and he starred on his first Arsenal start in 493 days, although it was Walcott who grabbed the vital goal to seal a comfortable but unspectacular win.
Manchester City have reached the fourth round in each of the last four seasons, with the Citizens winning the competition in both 2014 and 2016.
Despite controlling the game, City were given a scare as Claudio Yacob equalised for the hosts after 72 minutes.
The ties will be played on the week commencing October 20.