Nathaniel Clyne is set to spend up to another three months on the sidelines after undergoing an operation on his back injury.
Last season he played all but one of Liverpool's 38 Premier League games, making a total of 41 appearances in all competitions.
The player originally returned to light training with the club in September, however, he suffered a further setback.
Klopp had earlier said on Clyne's injury, "Nathaniel is working hard on his rehab and we have kept a close eye on his progress, but the reality is we are looking at some time still before he is back and available for selection".
With Alberto Moreno and Andrew Robertson in a battle for the left-back spot, Jurgen Klopp has just seven fit senior defender's to cover four position's ahead of a spell where the Reds will play 13 games in 45 days.
In order to correct the issue with his back, Clyne underwent "minor, corrective surgery", which is now expected to rule him out until February.
Clyne's injury has meant Gomez, who hadn't played regular first-team football in nearly two years, has been first-choice right-back and fourth-choice centre-back in Klopp's depleted defensive options.
Klopp had also asserted that Clyne would miss out on the matches in the group stages of the UEFA Champions League.
Defensive reinforcements may be looked at through the transfer market in January, but how much damage this injury could do to Liverpool's season until then remains to be seen.