"I can confirm that last night the Taliban launched a wave of attacks on police checkpoints in Maiwand and Zhari districts and we lost 22 fearless policemen", Kandahar governor spokesman Qudrat Khushbakht told AFP.
All four injured are in stable condition at USA medical facilities, according to the statement.
Four U.S. troops were injured Monday when a vehicle bomb detonated in Kandahar, the U.S. -NATO mission in Afghanistan said in a statement.
A vehicle-borne improvised explosive device attack left four U.S. soldiers wounded in Kandahar, Afghanistan on Monday, a USA military spokesman said.
Taliban has claimed responsibility for the incident.
The attack by a vehicle-borne improvised explosive device happened at about 2 p.m. local time, according to the statement from Resolute Support.
Twenty two policemen also lost their lives in the clash, officials confirmed.
A series of Taliban attacks over six hours on Tuesday on more than a dozen Afghanistan army checkpoints killed 22 policemen and wounded 15 in the southern province of Kandahar.
The Taliban attacks have not only increased lately, but they are even beginning to employ new tactics.
In August, Trump announced that American forces would stay in Afghanistan indefinitely, increasing attacks on militants and deploying more troops.